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Core Laboratories at Clark Atlanta University

This is a summary list of all core laboratories at Clark Atlanta University . The list includes links to more detailed information, which may also be found using the eagle-i search app.

CCRTD- Histology Core

Summary:

The mission of the CCRTD Research Support Core Facilities is to provide the scientists of CCRTD, Clark Atlanta University, and Atlanta University Center with access to modern technology, resources, and instruments essential for cutting-edge research in molecular biology, genomics, proteomics, cell biology, and biological imaging.



CCRTD-Biostatistics

Summary:

Biostatistics Core Facility provides support for statistical analysis of data collected from various researchers. These analyses assist in data interpretation and help researchers with experimental design. All the statistical analyses are performed by Dr. Fisseha Abebe who provides expert advice on how to interpret the statistical data. There are dedicated statistical and graphing software available for basic usage.



CCRTD-Cell Biology

Summary:

In CCRTD, we provide excellent support for Cell Biology research and advanced cell visualization applications. We have complete facilities for cell growth, handling, and storage. Cell Culture Facility maintains Cell Storage Cryo Tanks with uninterruptable liquid nitrogen supply and two separate Cell Culture rooms fully equipped with eight temperature and CO2-controlled Cell Growth Incubators, two Biological Safety Cabinets, Fluorescence-Activated Cell Sorter (FACS), two late model Inverted Digitized Microscope (Zeiss), one of which is fluorescence-enabled and possesses Z-stacking and live cell imaging capabilities, automated Cell Counter (Nexcelom Bioscience), and refrigerated storage for media and cell culture reagents.



CCRTD-Core Facilities

Summary:

The core facilities at Center for Cancer Research and Therapeutic Development (CCRTD) is to provide state-of-the-art research support including instruments, techniques, and related education and training for all investigators and researchers engaged in health-related scientific research in Clark Atlanta University. It now consists of eight research core facilities including Molecular Biology, Cell Biology, Histology, Cancer Genomics and Bioinformatics, Proteomics, Structural Biology and Drug Discovery, Biostatistics, and Prostate Cancer Biospecimen Repository Core Facilities. Each core has a faculty adviser in addition to four staff members responsible for the management and maintenance of the core facilities under the leadership of Dr. Valerie Odero-Marah.



CCRTD-Molecular Biology

Summary:

CCRTD Core Facilities house major equipment for DNA and RNA-based applications. We offer polymerase chain reaction ( PCR ) instruments including Real-Time PCR machine (I-Cycle, Bio-Rad), Liquid Scintillation Counter (Beckman Coulter), Lyophilizer and Freeze-Dryer for biological samples, Cell Porator, high-speed and ultra-high-speed Centrifuges, ultra-sensitive Balances, and other supporting equipment. DNA and RNA quantification can be carried out on Spectrophotometers, both single-cuvette (DU650, Beckman Coulter) and 96-well plate based. DNA and RNA can be visualized, digitized, and quantified using Gel Documentation system (Bio-Rad) or Multi-Mode Imager Typhoon 9410, in fluorescent, luminescent, UV, or visible wavelengths; time-resolved fluorescence option is available on BioTek Plate Imager. For X-Ray imaging, we maintain an Automated X-Ray processor and Dark Room; radioisotope imaging is also supported on Typhoon 9410.



CCRTD-Proteomics

Summary:

We are equipped for proteomics research including Cell Fractionation on one floor and tabletop Ultracentrifuges (Beckman Coulter) , Fast Protein Liquid Chromatography (FPLC), Two-Dimensional Protein Electrophoresis (Protean II, Biorad), and Gel Documentation Systems (one Bio-Rad and one Fuji Medical). Protein quantification can be done using UV-Vis spectrophotometry ( DU650, Beckman Coulter) or multimode Plate Spectrophotometers in both 96-well and 384-well micro well plate formats. Protein gels can also be visualized, digitized, and documented on Multi-Mode Imager Typhoon 9410.



CCRTD-Structural Biology

Summary:

CCRTD houses several major instruments to support structural studies of biological molecules, cells, modern cell, and molecular visualization applications. We have an Inverted Digitized Microscope (Zeiss) of general use, plus an advanced Fluorescence-enabled Inverted Digitized Microscope with Z-stacking and Live Cell Imaging modules (Zeiss). For advanced applications including In Situ Hybridization (ISH) and Immunohistochemistry (IHC), in addition to Zeiss microscope above we offer Confocal Fluorescent Microscope (Nikon). The latter is currently undergoing a major upgrade of computer system, software, and optics including addition of lasers.



Collaborative Center for Cancer Genomics and Bioinformatics Core

Summary:

The CCGC is being established in Clark Atlanta University as a collaborative effort between the CCRTD and the Ovarian Cancer Institute at Georgia Tech University (OCIGT). The operation will be based on Next-Generation sequencing technology which is the newest molecular genetics technology that allows biomedical scientists to address global genome composition, inter-individual variation, and global gene expression. For both CCRTD and OCIGT, it is essential to acquire this technology to be competitive in the cancer research field. CCRTD will house the “wet” laboratory which will prepare libraries and operate the instrument, while OCIGT will contribute bioinformatics support for processing the data and additional services to complement genomics data. Next-Generation sequencing technology produces massive amounts of sequence data, thus significant computational facilities including hardware, software, and highly qualified personnel are required in order to take advantage of the generated data. In addition, OCIGT will contribute patients sample procurement and complementary technologies including Affymetrix microarray technology and mass-spectroscopy analysis.



Found 8   core laboratories .

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